PPP4R4

Across TCGA cell cohorts, PPP4R4 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP4R4-associated genes across cancer lineages are MS4A4A, SERAC1, and AMD1. Each is linked with PPP4R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R4-to-partner and partner-to-PPP4R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by PPP4R4-low versus PPP4R4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R4→partner) and Y-score (partner→PPP4R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.144	+2.678	<.001	.003	3	1
LARGE_INTESTINE	SERAC1 →	+0.622	+3.067	.009	.009	3	1
LARGE_INTESTINE	AMD1 →	+0.493	+3.064	.007	.009	3	1
LARGE_INTESTINE	FAM124A →	+0.649	+3.295	.003	.006	3	1
LARGE_INTESTINE	DRD3 →	+0.007	+2.977	<.001	.006	3	1
LARGE_INTESTINE	POLR1C →	+0.485	+3.067	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MS4A4A by PPP4R4 expression — LARGE_INTESTINE

Explore this box plot interactively →