PPP4R3B

Across TCGA patient cohorts, PPP4R3B mutation is significantly associated with the RNA expression of many other genes, with 2,153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R3B-associated genes across cancer lineages are TP53TG3, RNU6-937P, and RNU6-1274P. Each is linked with PPP4R3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R3B-to-partner and partner-to-PPP4R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53TG3 grouped by PPP4R3B-low versus PPP4R3B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R3B→partner) and Y-score (partner→PPP4R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TP53TG3 →	+0.017	+3.411	<.001	.005	3	2
BLCA	RNU6-937P →	+0.336	+2.916	.007	.003	3	2
READ	RNU6-1274P →	+0.403	+4.925	<.001	.004	3	2
READ	OR4F13P →	+0.034	+4.421	.001	.009	3	2
READ	OR6K5P →	+0.042	+5.257	<.001	.002	3	2
READ	HMGB1P7 →	+0.131	+4.202	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,153 associations by consensus.

TP53TG3 by PPP4R3B expression — BLCA

Explore this box plot interactively →