PPP4R3B

Across TCGA cell cohorts, PPP4R3B mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP4R3B-associated genes across cancer lineages are SERPINA4, SERPINA7, and FSHB. Each is linked with PPP4R3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R3B-to-partner and partner-to-PPP4R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA4 grouped by PPP4R3B-low versus PPP4R3B-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R3B→partner) and Y-score (partner→PPP4R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA4 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FSHB →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2M2 →	+0.033	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	LYZL1 →	+0.013	+3.662	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

SERPINA4 by PPP4R3B expression — BLOOD_Myeloma

Explore this box plot interactively →