PPP4R3A

Across TCGA pan-cancer cohorts, PPP4R3A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP4R3A data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PPP4R3A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP4R3A expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where PPP4R3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.945	0.490	.002	25	view →
CCRCC	DFS	Tertile	All	1.000	0.686	.015	15	view →
HNSC	OS	Median	IV	0.744	0.925	.011	15	view →
PDAC	DFS	Tertile	IV	0.934	0.235	.024	9	view →
UCEC	DFS	Median	All	0.936	1.000	.022	2	view →
GBM	OS	Median	All	0.520	0.300	.034	1	view →
LUAD	OS	Quartile	All	0.708	1.000	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP4R3A–LSCC (DFS)

Open the LSCC breakdown →