PPP4R3A

Across TCGA pan-cancer cohorts, PPP4R3A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPP4R3A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP4R3A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP4R3A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where PPP4R3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP4R3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.481	<.001	10	view →
THCA	All	II,III,IV	−0.453	<.001	10	view →
BLCA	Male	III,IV	+0.757	<.001	9	view →
LIHC	All	II,III,IV	+0.659	<.001	8	view →
STAD	All	II,III,IV	+0.612	.001	6	view →
CHOL	All	All	+1.012	.001	4	view →
KICH	All	All	−0.591	<.001	4	view →
BRCA	All	II,III,IV	+0.249	<.001	4	view →
LUSC	All	All	+0.255	.003	3	view →
COAD	Female	All	−0.529	.019	2	view →
ESCA	All	All	+0.487	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPP4R3A–HNSC

Open the HNSC breakdown →