PPP4R3A

Across TCGA patient cohorts, PPP4R3A mutation is significantly associated with the RNA expression of many other genes, with 1,358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R3A-associated genes across cancer lineages are RNA5SP198, ZDHHC20P2, and MIR5007. Each is linked with PPP4R3A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP4R3A-to-partner and partner-to-PPP4R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by PPP4R3A-low versus PPP4R3A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R3A→partner) and Y-score (partner→PPP4R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP198 →	+0.364	+5.800	<.001	.003	3	3
BRCA	ZDHHC20P2 →	+0.122	+5.317	<.001	.006	3	2
KIRC	MIR5007 →	+0.473	+8.025	<.001	.007	3	2
UCEC	ACKR3 →	-0.816	-3.807	<.001	<.001	3	2
UCEC	DNAJC5B →	+0.418	+3.212	<.001	<.001	3	2
CESC	RPL21P88 →	+0.075	+2.799	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,358 associations by consensus.

RNA5SP198 by PPP4R3A expression — BRCA

Explore this box plot interactively →