PPP4R3A

Across TCGA patient cohorts, PPP4R3A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R3A-associated genes across cancer lineages are FASN, mTOR_pS2448, and p62 Lck ligand. Each is linked with PPP4R3A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R3A-to-partner and partner-to-PPP4R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PPP4R3A-low versus PPP4R3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R3A→partner) and Y-score (partner→PPP4R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.383	+1.700	.009	.042	3	2
UCEC	mTOR_pS2448 →	-0.130	-2.680	.020	.006	3	2
UCEC	p62 Lck ligand →	+0.544	+2.662	<.001	<.001	3	2
UCEC	ATM →	-0.435	-1.415	.010	.046	3	2
UCEC	EGFR_pY1068 →	-0.252	-2.584	.007	.010	3	1
UCEC	eIF4E →	+0.170	+3.335	.032	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FASN by PPP4R3A expression — UCEC

Explore this box plot interactively →