PPP4R3A

Across TCGA cell cohorts, PPP4R3A mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP4R3A-associated genes across cancer lineages are SH3GL2, RASGEF1C, and GPHB5. Each is linked with PPP4R3A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R3A-to-partner and partner-to-PPP4R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by PPP4R3A-low versus PPP4R3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R3A→partner) and Y-score (partner→PPP4R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.504	+3.252	<.001	.009	3	1
LARGE_INTESTINE	RASGEF1C →	+0.220	+3.555	.003	.003	3	1
CNS	GPHB5 →	+0.170	+6.357	<.001	<.001	3	1
CNS	ZPBP2 →	+0.044	+5.754	.002	.002	3	1
CNS	DPPA3 →	+0.508	+4.981	<.001	.008	3	1
CNS	PRAMEF15 →	+0.356	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

SH3GL2 by PPP4R3A expression — LARGE_INTESTINE

Explore this box plot interactively →