PPP4R2

Across TCGA cell cohorts, PPP4R2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,924 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP4R2-associated GO terms across cancer lineages are mRNA destabilization, RNA destabilization, and Regulation of double-strand break repair via homologous recombination. Each is linked with PPP4R2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PPP4R2-to-partner and partner-to-PPP4R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA destabilization grouped by PPP4R2-low versus PPP4R2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R2→partner) and Y-score (partner→PPP4R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	mRNA destabilization →	+0.071	+0.662	<.001	<.001	3	17
LUNG_SCLC	RNA destabilization →	+0.068	+0.697	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair via homologous recombination →	+0.083	+1.047	<.001	<.001	3	15
BREAST	Regulation of double-strand break repair →	+0.066	+0.713	<.001	.001	3	15
LUNG_SCLC	Transcription elongation by RNA polymerase II →	+0.088	+0.591	<.001	<.001	3	15
KIDNEY	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.072	+1.172	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,924 associations by consensus.

mRNA destabilization by PPP4R2 expression — LUNG_SCLC

Explore this box plot interactively →