PPP4R2

Across TCGA pan-cancer cohorts, PPP4R2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PPP4R2 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PPP4R2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP4R2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

BRCA, SKCM, and LGG are the cancer types where PPP4R2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.935	0.802	.001	42	view →
SKCM	DFS	Tertile	II,III,IV	0.282	0.121	<.001	37	view →
LGG	OS	Median	All	0.342	0.578	<.001	33	view →
SARC	OS	Tertile	All	0.367	0.690	<.001	33	view →
UCEC	DFS	Tertile	III,IV	0.875	0.720	.006	28	view →
UCS	DFS	Tertile	IV	0.874	0.237	.024	24	view →
KIRC	OS	Tertile	All	0.733	0.526	.002	23	view →
OV	DFS	Median	III,IV	0.184	0.123	.012	22	view →
ACC	DFS	Quartile	All	0.226	0.683	.005	19	view →
KICH	DFS	Median	All	0.722	0.946	.013	12	view →
GBM	OS	Median	All	0.518	0.310	.022	12	view →
LUSC	DFS	Quartile	III,IV	0.517	0.811	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PPP4R2–BRCA (DFS)

Open the BRCA breakdown →