PPP4R1-AS1

Across TCGA pan-cancer cohorts, PPP4R1-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PPP4R1-AS1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PPP4R1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP4R1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and OV show a favorable association.

CESC, UCS, and LGG are the cancer types where PPP4R1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	II,III,IV	0.652	0.845	.013	50	view →
UCS	DFS	Median	IV	0.885	0.440	.015	36	view →
LGG	DFS	Median	All	0.664	0.805	<.001	34	view →
UVM	DFS	Tertile	III,IV	0.196	1.000	.002	32	view →
KIRC	OS	Median	II,III,IV	0.427	0.610	.002	28	view →
OV	OS	Quartile	III,IV	0.468	0.334	.003	20	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	18	view →
BLCA	DFS	Tertile	IV	0.257	0.640	.008	12	view →
UCEC	OS	Quartile	All	0.923	0.849	.025	10	view →
ACC	DFS	Median	II,III,IV	0.404	0.716	.015	9	view →
MESO	OS	Median	All	0.693	0.325	.025	8	view →
ESCA	DFS	Quartile	II,III,IV	0.864	0.355	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PPP4R1-AS1–CESC (DFS)

Open the CESC breakdown →