PPP4R1-AS1

Across TCGA pan-cancer cohorts, PPP4R1-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PPP4R1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PPP4R1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP4R1-AS1 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

LIHC, KIRC, and LUSC are the cancer types where PPP4R1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP4R1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.251	<.001	6	view →
KIRC	Male	II,III,IV	−0.236	<.001	6	view →
LUSC	All	All	−0.353	.002	4	view →
HNSC	Male	II,III,IV	+0.273	.022	4	view →
KICH	All	All	−0.367	.013	3	view →
CHOL	All	All	+0.690	.005	2	view →
LUAD	Female	All	−0.335	.020	2	view →
BLCA	All	III,IV	+0.427	.036	1	view →
KIRP	All	All	+0.323	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PPP4R1-AS1–LIHC

Open the LIHC breakdown →