Across TCGA patient cohorts, PPP3R2 mutation is significantly associated with the RNA expression of many other genes, with 2,758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3R2-associated genes across cancer lineages are MRPS15, POLR3KP2, and POLE2. Each is linked with PPP3R2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP3R2-to-partner and partner-to-PPP3R2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3R2→partner) and Y-score (partner→PPP3R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS15 →	+0.498	+2.341	<.001	.003	3	3
UCEC	POLR3KP2 →	+0.174	+2.048	<.001	.003	3	3
UCEC	POLE2 →	+0.505	+2.343	.001	.003	3	2
UCEC	CDKN3 →	+0.749	+3.178	<.001	<.001	3	2
UCEC	PLTP →	-0.770	-1.736	.003	.007	3	2
UCEC	SLCO4A1 →	+1.060	+1.747	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,758 associations by consensus.

Exploration

PPP3R2 survival (RNA) · tumor vs normal (RNA) · all PPP3R2 data types