Across TCGA patient cohorts, PPP3R2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3R2-associated genes across cancer lineages are EGFR_pY1068, JNK2, and PCNA. Each is linked with PPP3R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP3R2-to-partner and partner-to-PPP3R2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3R2→partner) and Y-score (partner→PPP3R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.202	-2.807	.025	.003	3	2
UCEC	JNK2 →	+0.219	+1.817	.002	.015	3	2
UCEC	PCNA →	+0.211	+1.765	.006	.013	3	2
UCEC	PKC-a →	+0.371	+1.820	.011	.014	3	2
UCEC	Caspase-8 →	-0.191	-1.880	.035	.014	3	2
SKCM	AMPK_pT172 →	+0.360	+2.584	.018	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

PPP3R2 survival (RNA) · tumor vs normal (RNA) · all PPP3R2 data types