Across TCGA patient cohorts, PPP3R1 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3R1-associated genes across cancer lineages are COPS8P1, RN7SL711P, and RNVU1-28. Each is linked with PPP3R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP3R1-to-partner and partner-to-PPP3R1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3R1→partner) and Y-score (partner→PPP3R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS8P1 →	+0.140	+3.900	<.001	<.001	3	1
UCEC	RN7SL711P →	+0.276	+2.850	.008	.007	3	1
UCEC	RNVU1-28 →	+1.391	+3.220	<.001	.003	3	1
UCEC	SSTR5 →	+0.673	+3.728	.005	.003	3	1
UCEC	RN7SL147P →	+0.282	+3.550	<.001	.001	3	1
UCEC	MIR548AQ →	+0.536	+3.294	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

PPP3R1 survival (RNA) · tumor vs normal (RNA) · all PPP3R1 data types