PPP3CB

Across TCGA pan-cancer cohorts, PPP3CB Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP3CB data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP3CB Mutation is associated with better overall survival. In most high-consensus cancer types, elevated PPP3CB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LGG, and LUSC are the cancer types where PPP3CB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.459	.012	32	view →
LGG	OS	Median	All	0.133	0.811	<.001	12	view →
LUSC	OS	Median	II,III,IV	0.205	0.631	.019	12	view →
BLCA	DFS	Median	III,IV	0.168	0.576	.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ESCA	OS	Median	II,III,IV	0.277	0.686	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP3CB–UCEC (OS)

Open the UCEC breakdown →