PPP3CB

Across TCGA pan-cancer cohorts, PPP3CB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP3CB data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPP3CB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPP3CB expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

LUAD, GBM, and PDAC are the cancer types where PPP3CB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.245	0.743	.012	9	view →
GBM	DFS	Median	All	0.792	0.647	.017	2	view →
PDAC	OS	Tertile	II,III,IV	0.781	0.893	.022	2	view →
HNSC	OS	Quartile	All	0.852	0.661	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP3CB–LUAD (OS)

Open the LUAD breakdown →