PPP3CA

Across TCGA pan-cancer cohorts, PPP3CA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP3CA data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PPP3CA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP3CA expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

COAD, LSCC, and LUAD are the cancer types where PPP3CA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.910	.011	72	view →
LSCC	OS	Median	II,III,IV	0.577	0.926	.001	41	view →
LUAD	OS	Tertile	III,IV	0.173	1.000	.005	13	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP3CA–COAD (DFS)

Open the COAD breakdown →