PPP3CA

Across TCGA patient cohorts, PPP3CA protein abundance is significantly associated with the RNA expression of many other genes, with 11,464 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPP3CA-associated genes across cancer lineages are TMEM45A, PDGFC, and PRICKLE2. Each is linked with PPP3CA in more than 5 cancer types. Because this analysis shows association rather than direction, both PPP3CA-to-partner and partner-to-PPP3CA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP3CA versus TMEM45A in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CA→partner) and Y-score (partner→PPP3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM45A →	+1.438	+0.313	<.001	<.001	3	6
LSCC	PDGFC →	+0.905	+0.319	<.001	<.001	3	5
BRCA	PRICKLE2 →	+0.813	+0.325	<.001	<.001	3	5
LSCC	NTM →	+0.879	+0.264	<.001	.001	3	5
HNSC	MMP28 →	+1.306	+0.228	.001	<.001	3	5
HNSC	TLL1 →	+1.143	+0.253	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,464 associations by consensus.

PPP3CA vs TMEM45A — LSCC

Explore this scatter interactively →