PPP3CA

Across TCGA patient cohorts, PPP3CA mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3CA-associated genes across cancer lineages are EGFR_pY1068, Rab25, and Shc_pY317. Each is linked with PPP3CA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP3CA-to-partner and partner-to-PPP3CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PPP3CA-low versus PPP3CA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CA→partner) and Y-score (partner→PPP3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.272	-2.247	<.001	.001	3	2
UCEC	Rab25 →	-0.434	-4.169	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.168	-3.700	<.001	.001	3	2
UCEC	STAT5a →	+0.399	+2.584	.001	.001	3	2
UCEC	ATM →	-0.454	-1.777	.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.648	+1.522	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by PPP3CA expression — UCEC

Explore this box plot interactively →