PPP3CA

Across TCGA cell cohorts, PPP3CA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,452 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PPP3CA-associated GO terms across cancer lineages are Regulation of saliva secretion, Positive regulation of calcium ion-dependent exocytosis of neurotransmitter, and Regulation of angiotensin-activated signaling pathway. Each is linked with PPP3CA in more than 19 cancer types. Because this analysis shows association rather than direction, both PPP3CA-to-partner and partner-to-PPP3CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of saliva secretion grouped by PPP3CA-low versus PPP3CA-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CA→partner) and Y-score (partner→PPP3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of saliva secretion →	+1.541	+1.329	.003	.009	2	20
OVARY	Positive regulation of calcium ion-dependent exocytosis of neurotransmitter →	+1.245	+1.094	<.001	<.001	3	18
LIVER	Regulation of angiotensin-activated signaling pathway →	+0.195	+1.677	<.001	<.001	3	17
SOFT_TISSUE	Positive regulation of glomerulus development →	+1.430	+2.759	<.001	<.001	3	17
OVARY	Positive regulation of synaptic vesicle exocytosis →	+1.275	+1.327	<.001	<.001	3	16
SOFT_TISSUE	Regulation of glomerulus development →	+1.125	+2.064	<.001	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,452 associations by consensus.

Regulation of saliva secretion by PPP3CA expression — LIVER

Explore this box plot interactively →