PPP2R5E

Across TCGA pan-cancer cohorts, PPP2R5E Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP2R5E data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PPP2R5E Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R5E expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, BLCA, and UCEC are the cancer types where PPP2R5E Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.108	0.797	<.001	18	view →
BLCA	OS	Median	IV	0.089	0.599	<.001	12	view →
UCEC	DFS	Median	All	0.925	0.619	.018	10	view →
HNSC	DFS	Median	All	0.225	0.628	.011	6	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP2R5E–LUSC (DFS)

Open the LUSC breakdown →