PPP2R5E

Across TCGA pan-cancer cohorts, PPP2R5E RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPP2R5E’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP2R5E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP2R5E is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where PPP2R5E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R5E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.799	<.001	12	view →
LIHC	Female	II,III,IV	+0.620	<.001	8	view →
LUAD	Male	II,III,IV	+0.636	<.001	6	view →
LUSC	Male	All	+0.398	<.001	6	view →
KIRC	All	II,III,IV	−0.344	<.001	6	view →
BRCA	All	II,III,IV	+0.317	<.001	6	view →
THCA	All	All	−0.298	<.001	5	view →
CHOL	All	All	+1.332	<.001	4	view →
COAD	All	All	−0.329	.009	3	view →
ESCA	All	All	+0.723	.003	2	view →
READ	All	All	−0.547	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPP2R5E–HNSC

Open the HNSC breakdown →