PPP2R5E

Across TCGA patient cohorts, PPP2R5E mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5E-associated genes across cancer lineages are eEF2, eIF4E, and c-Met_pY1235. Each is linked with PPP2R5E in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5E-to-partner and partner-to-PPP2R5E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PPP2R5E-low versus PPP2R5E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5E→partner) and Y-score (partner→PPP2R5E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.281	+2.584	.013	.010	3	2
UCEC	eIF4E →	+0.203	+3.100	.002	<.001	3	2
UCEC	c-Met_pY1235 →	+0.085	+2.009	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.319	-2.754	<.001	<.001	3	1
UCEC	eIF4G →	+0.211	+2.115	.033	.016	3	1
UCEC	A-Raf_pS299 →	-0.125	-2.115	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eEF2 by PPP2R5E expression — UCEC

Explore this box plot interactively →