PPP2R5E

Across TCGA cell cohorts, PPP2R5E mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP2R5E-associated genes across cancer lineages are SLC15A5, C20orf85, and IL22. Each is linked with PPP2R5E in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5E-to-partner and partner-to-PPP2R5E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC15A5 grouped by PPP2R5E-low versus PPP2R5E-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5E→partner) and Y-score (partner→PPP2R5E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	OR10K2 →	+0.047	+3.705	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.020	+3.551	<.001	.009	3	1
BLOOD_Leukemia	TCEAL6 →	+0.026	+4.133	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SLC15A5 by PPP2R5E expression — LARGE_INTESTINE

Explore this box plot interactively →