PPP2R5D

Across TCGA patient cohorts, PPP2R5D mutation is significantly associated with the RNA expression of many other genes, with 3,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5D-associated genes across cancer lineages are S100A11P9, EIF4EP5, and C4BPAP1. Each is linked with PPP2R5D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5D-to-partner and partner-to-PPP2R5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100A11P9 grouped by PPP2R5D-low versus PPP2R5D-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5D→partner) and Y-score (partner→PPP2R5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	S100A11P9 →	+1.239	+4.174	<.001	.009	3	2
BLCA	EIF4EP5 →	+0.052	+2.653	<.001	.005	3	2
BLCA	C4BPAP1 →	+0.251	+3.120	<.001	.001	3	2
LIHC	RNU6-1141P →	+0.412	+6.232	<.001	<.001	3	2
BLCA	RNU6-767P →	+0.446	+2.962	.004	.003	3	2
COAD	RNA5SP20 →	+0.906	+4.372	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,677 associations by consensus.

S100A11P9 by PPP2R5D expression — LIHC

Explore this box plot interactively →