PPP2R5C

Across TCGA pan-cancer cohorts, PPP2R5C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPP2R5C data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PPP2R5C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R5C expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

LSCC, HNSC, and GBM are the cancer types where PPP2R5C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	9	view →
HNSC	DFS	Quartile	III,IV	0.817	0.511	.015	7	view →
GBM	OS	Median	All	0.933	0.774	.018	5	view →
PDAC	DFS	Tertile	IV	0.550	0.217	.024	5	view →
LUAD	DFS	Tertile	II,III,IV	0.809	0.939	.007	5	view →
CCRCC	DFS	Quartile	III,IV	0.889	0.548	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPP2R5C–LSCC (DFS)

Open the LSCC breakdown →