PPP2R5C

Across TCGA pan-cancer cohorts, PPP2R5C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPP2R5C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP2R5C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP2R5C is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where PPP2R5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.470	<.001	10	view →
LIHC	All	II,III,IV	+0.635	<.001	8	view →
THCA	Female	All	−0.397	<.001	8	view →
KIRC	All	II,III,IV	−0.306	<.001	6	view →
CHOL	All	All	+0.987	.001	5	view →
LUAD	Female	II,III,IV	−0.288	.004	4	view →
KICH	All	All	−0.415	.003	3	view →
BLCA	All	IV	−0.575	.034	2	view →
PRAD	All	All	−0.202	.019	2	view →
ESCA	All	All	+0.644	.011	1	view →
KIRP	Male	All	−0.208	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPP2R5C–HNSC

Open the HNSC breakdown →