PPP2R5C

Across TCGA patient cohorts, PPP2R5C mutation is significantly associated with the RNA expression of many other genes, with 2,991 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5C-associated genes across cancer lineages are RN7SKP4, RNU4-15P, and RN7SL134P. Each is linked with PPP2R5C in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R5C-to-partner and partner-to-PPP2R5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP4 grouped by PPP2R5C-low versus PPP2R5C-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5C→partner) and Y-score (partner→PPP2R5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SKP4 →	+0.152	+3.715	.005	.008	3	3
SKCM	RNU4-15P →	+0.367	+5.970	<.001	.002	3	2
UCEC	RN7SL134P →	+0.067	+1.862	.009	.001	3	2
CESC	BANF1P5 →	+0.190	+3.381	<.001	.003	3	2
COAD	RN7SL25P →	+0.431	+3.899	<.001	.003	3	2
UCEC	SRXN1 →	+0.316	+1.401	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,991 associations by consensus.

RN7SKP4 by PPP2R5C expression — LUSC

Explore this box plot interactively →