PPP2R5C

Across TCGA patient cohorts, PPP2R5C mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5C-associated genes across cancer lineages are P-Cadherin, Rab25, and Di-Ras3. Each is linked with PPP2R5C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5C-to-partner and partner-to-PPP2R5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by PPP2R5C-low versus PPP2R5C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5C→partner) and Y-score (partner→PPP2R5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.103	-1.755	.020	.013	3	2
UCEC	Rab25 →	-0.219	-1.362	.033	.034	3	2
UCEC	Di-Ras3 →	-0.110	-2.687	.017	.005	3	2
UCEC	14-3-3_beta →	-0.074	-1.651	.017	.019	3	1
UCEC	eIF4E →	+0.147	+2.713	.024	.003	3	1
UCEC	ERK2 →	+0.122	+1.700	.041	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

P-Cadherin by PPP2R5C expression — UCEC

Explore this box plot interactively →