PPP2R3B

Across TCGA patient cohorts, PPP2R3B mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R3B-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and c-Kit. Each is linked with PPP2R3B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R3B-to-partner and partner-to-PPP2R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PPP2R3B-low versus PPP2R3B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3B→partner) and Y-score (partner→PPP2R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.187	+3.000	.001	.036	3	3
UCEC	ATM →	-0.528	-2.247	.001	.001	3	3
STAD	c-Kit →	-0.355	-3.000	.030	.036	3	2
UCEC	MEK1 →	+0.451	+2.700	<.001	.005	3	2
UCEC	p90 RSK →	+0.168	+1.515	.016	.018	3	2
UCEC	4E-BP1 →	+0.299	+2.489	.002	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by PPP2R3B expression — STAD

Explore this box plot interactively →