PPP2R3B

Across TCGA cell cohorts, PPP2R3B mutation is significantly associated with the RNA expression of many other genes, with 566 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP2R3B-associated genes across cancer lineages are OR2M3, OR10G2, and OR4F5. Each is linked with PPP2R3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R3B-to-partner and partner-to-PPP2R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M3 grouped by PPP2R3B-low versus PPP2R3B-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3B→partner) and Y-score (partner→PPP2R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR2M3 →	+0.006	+4.906	<.001	.006	3	2
OESOPHAGUS	OR10G2 →	+0.033	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4F5 →	+0.007	+3.887	<.001	.002	3	1
BLOOD_Leukemia	GZMK →	+0.566	+4.622	<.001	<.001	3	1
BLOOD_Leukemia	TTLL2 →	+0.394	+3.540	<.001	.005	3	1
BLOOD_Leukemia	SLC35G3 →	+0.045	+3.704	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 566 associations by consensus.

OR2M3 by PPP2R3B expression — OESOPHAGUS

Explore this box plot interactively →