PPP2R3B

Across TCGA cell cohorts, PPP2R3B mutation is significantly associated with the mutation status of many other genes, with 5,660 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP2R3B-associated genes across cancer lineages are TRPA1, BICRA, and EPS8L1. Each is linked with PPP2R3B in more than 4 cancer types. Because this analysis shows association rather than direction, both PPP2R3B-to-partner and partner-to-PPP2R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPA1 grouped by PPP2R3B-low versus PPP2R3B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3B→partner) and Y-score (partner→PPP2R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRPA1 →	+3.260	+3.498	.001	.001	1	5
SKIN	BICRA →	+2.830	+3.548	.009	.009	1	5
CNS	EPS8L1 →	+4.459	+5.277	.005	.005	1	4
CNS	SHANK2 →	+4.459	+5.277	.005	.005	1	4
CNS	POLR2B →	+4.459	+5.277	.005	.005	1	4
LUNG_NSCLC_LUAD	HIVEP2 →	+2.981	+3.266	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,660 associations by consensus.

TRPA1 by PPP2R3B expression — BLOOD_Leukemia

Explore this box plot interactively →