PPP2R2D

Across TCGA pan-cancer cohorts, PPP2R2D mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP2R2D data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP2R2D mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP2R2D expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where PPP2R2D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.858	0.412	.004	34	view →
LUAD	DFS	Quartile	III,IV	0.366	0.854	.006	25	view →
LSCC	OS	Tertile	II,III,IV	0.616	0.956	.004	19	view →
PDAC	DFS	Median	All	0.921	0.682	<.001	19	view →
OV	DFS	Median	All	0.907	0.632	.028	4	view →
HNSC	OS	Quartile	IV	0.932	0.632	.031	3	view →
GBM	DFS	Median	All	0.786	0.649	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP2R2D–CCRCC (DFS)

Open the CCRCC breakdown →