PPP2R2C

Across TCGA patient cohorts, PPP2R2C mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R2C-associated genes across cancer lineages are GAPDH, ATM, and JNK2. Each is linked with PPP2R2C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R2C-to-partner and partner-to-PPP2R2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PPP2R2C-low versus PPP2R2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2C→partner) and Y-score (partner→PPP2R2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.501	+1.662	.004	.010	3	2
UCEC	ATM →	-0.726	-2.263	<.001	<.001	3	2
UCEC	JNK2 →	+0.253	+2.424	<.001	.001	3	2
UCEC	Ku80 →	+0.218	+1.713	.005	.024	3	2
UCEC	mTOR_pS2448 →	-0.149	-2.308	.002	.005	3	2
UCEC	Notch1 →	+0.160	+1.290	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

GAPDH by PPP2R2C expression — UCEC

Explore this box plot interactively →