PPP2R2C

Across TCGA pan-cancer cohorts, PPP2R2C RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PPP2R2C data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PPP2R2C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPP2R2C expression acts as an unfavorable survival marker, although some lineages such as UCEC and ACC show a favorable association.

KIRC, LUAD, and UCEC are the cancer types where PPP2R2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.564	0.701	<.001	130	view →
LUAD	OS	Quartile	All	0.744	0.873	<.001	96	view →
UCEC	DFS	Quartile	All	0.822	0.464	.001	72	view →
ACC	DFS	Quartile	III,IV	0.509	0.055	.001	57	view →
LIHC	OS	Quartile	All	0.591	0.806	<.001	48	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	43	view →
KIRP	DFS	Quartile	All	0.730	0.915	<.001	35	view →
BLCA	DFS	Median	All	0.434	0.584	<.001	33	view →
LGG	DFS	Quartile	All	0.888	0.763	.001	22	view →
UCS	OS	Median	All	0.550	0.819	.006	14	view →
PAAD	OS	Quartile	II,III,IV	0.496	0.700	.013	9	view →
SARC	DFS	Quartile	All	0.710	0.546	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PPP2R2C–KIRC (OS)

Open the KIRC breakdown →