PPP2R2C

Across TCGA cell cohorts, PPP2R2C mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP2R2C-associated genes across cancer lineages are PAX4, LIPK, and C1QBP. Each is linked with PPP2R2C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R2C-to-partner and partner-to-PPP2R2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX4 grouped by PPP2R2C-low versus PPP2R2C-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2C→partner) and Y-score (partner→PPP2R2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PAX4 →	+0.022	+4.930	<.001	.008	3	1
SOFT_TISSUE	LIPK →	+0.032	+4.930	<.001	.008	3	1
LARGE_INTESTINE	C1QBP →	+0.714	+3.131	.004	.008	3	1
LARGE_INTESTINE	ULBP3 →	+0.895	+3.064	.005	.009	3	1
LARGE_INTESTINE	FRMPD2 →	+0.554	+3.321	<.001	.005	3	1
LARGE_INTESTINE	CALML5 →	+0.909	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PAX4 by PPP2R2C expression — SOFT_TISSUE

Explore this box plot interactively →