PPP2R2B

Across TCGA patient cohorts, PPP2R2B mutation is significantly associated with the RNA expression of many other genes, with 4,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R2B-associated genes across cancer lineages are TEDC2, RNU6-33P, and ATP5F1A. Each is linked with PPP2R2B in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP2R2B-to-partner and partner-to-PPP2R2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEDC2 grouped by PPP2R2B-low versus PPP2R2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2B→partner) and Y-score (partner→PPP2R2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TEDC2 →	+0.505	+1.962	<.001	<.001	3	4
BLCA	RNU6-33P →	+0.542	+3.577	.004	.009	3	3
UCEC	ATP5F1A →	+0.392	+2.245	.001	.001	3	3
UCEC	SFXN1 →	+0.574	+2.678	<.001	<.001	3	3
UCEC	CHAF1A →	+0.789	+3.065	<.001	<.001	3	3
UCEC	MCAT →	+0.330	+2.627	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,900 associations by consensus.

TEDC2 by PPP2R2B expression — UCEC

Explore this box plot interactively →