PPP2R2B

Across TCGA pan-cancer cohorts, PPP2R2B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PPP2R2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPP2R2B RNA is repressed in tumor relative to normal tissue. In most cancer types PPP2R2B is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where PPP2R2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.279	<.001	12	view →
HNSC	All	IV	+1.022	<.001	12	view →
KICH	Male	All	−1.909	<.001	11	view →
COAD	Male	II,III,IV	−0.485	<.001	11	view →
KIRP	Male	All	−1.198	<.001	9	view →
THCA	Male	III,IV	−1.061	<.001	8	view →
BRCA	All	III,IV	−0.646	<.001	6	view →
BLCA	All	All	−1.295	.001	5	view →
UCEC	All	All	−1.259	.002	4	view →
READ	All	All	−0.700	.003	4	view →
STAD	All	All	−0.386	.001	4	view →
ESCA	All	II,III,IV	−1.174	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PPP2R2B–KIRC

Open the KIRC breakdown →