PPP2R2B

Across TCGA patient cohorts, PPP2R2B mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R2B-associated genes across cancer lineages are 4E-BP1, HER2_pY1248, and EGFR_pY1068. Each is linked with PPP2R2B in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP2R2B-to-partner and partner-to-PPP2R2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PPP2R2B-low versus PPP2R2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2B→partner) and Y-score (partner→PPP2R2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.357	+2.378	<.001	<.001	3	4
LUAD	HER2_pY1248 →	-0.361	-3.000	.032	.036	3	2
UCEC	EGFR_pY1068 →	-0.241	-1.925	.002	.004	3	2
UCEC	eIF4E →	+0.150	+2.087	.026	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.134	-1.765	.012	.013	3	2
UCEC	AR →	-0.292	-1.289	.014	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

4E-BP1 by PPP2R2B expression — UCEC

Explore this box plot interactively →