PPP2R2B

Across TCGA cell cohorts, PPP2R2B mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP2R2B-associated genes across cancer lineages are LGALS13, FTMT, and PRSS45P. Each is linked with PPP2R2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R2B-to-partner and partner-to-PPP2R2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGALS13 grouped by PPP2R2B-low versus PPP2R2B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2B→partner) and Y-score (partner→PPP2R2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LGALS13 →	+0.062	+5.369	.002	.004	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
SOFT_TISSUE	PRSS45P →	+0.206	+4.930	<.001	.008	3	1
SOFT_TISSUE	MROH5 →	+0.028	+4.930	<.001	.008	3	1
LUNG_SCLC	CLEC6A →	+0.126	+5.029	<.001	.006	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

LGALS13 by PPP2R2B expression — SOFT_TISSUE

Explore this box plot interactively →