PPP2R1B

Across TCGA pan-cancer cohorts, PPP2R1B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP2R1B data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PPP2R1B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPP2R1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

GBM, UCEC, and CCRCC are the cancer types where PPP2R1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.277	0.626	<.001	34	view →
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	24	view →
CCRCC	OS	Quartile	All	1.000	0.776	.013	19	view →
HNSC	DFS	Tertile	II,III,IV	0.798	0.541	.007	15	view →
LUAD	DFS	Median	All	0.898	1.000	.021	11	view →
LSCC	OS	Median	III,IV	0.705	1.000	.004	11	view →
PDAC	DFS	Quartile	All	0.576	0.310	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP2R1B–GBM (OS)

Open the GBM breakdown →