PPP2R1A

Across TCGA pan-cancer cohorts, PPP2R1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP2R1A data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP2R1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPP2R1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where PPP2R1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.992	0.933	.024	4	view →
CCRCC	DFS	Tertile	III,IV	0.830	0.198	.024	3	view →
GBM	DFS	Tertile	All	0.229	0.445	.044	2	view →
PDAC	OS	Tertile	II,III,IV	0.615	0.478	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP2R1A–HNSC (OS)

Open the HNSC breakdown →