PPP2CB

Across TCGA patient cohorts, PPP2CB mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2CB-associated genes across cancer lineages are PCNA, EGFR_pY1068, and eIF4E. Each is linked with PPP2CB in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2CB-to-partner and partner-to-PPP2CB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PPP2CB-low versus PPP2CB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2CB→partner) and Y-score (partner→PPP2CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.223	+3.321	.010	.009	3	2
UCEC	EGFR_pY1068 →	-0.261	-1.906	.009	.016	3	1
UCEC	eIF4E →	+0.199	+3.013	.019	.018	3	1
UCEC	FoxM1 →	+0.215	+2.469	.039	.010	3	1
UCEC	HSP70 →	-0.348	-3.575	.031	.002	3	1
UCEC	INPP4B →	-0.311	-1.893	.016	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PCNA by PPP2CB expression — UCEC

Explore this box plot interactively →