PPP2CB

Across TCGA pan-cancer cohorts, PPP2CB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PPP2CB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PPP2CB RNA is repressed in tumor relative to normal tissue. In most cancer types PPP2CB is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and COAD are the cancer types where PPP2CB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2CB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.598	<.001	11	view →
LUAD	Female	III,IV	−1.182	<.001	9	view →
COAD	Female	II,III,IV	−0.660	<.001	9	view →
BLCA	All	All	−0.652	.002	9	view →
KICH	Female	II,III,IV	−1.449	<.001	7	view →
LUSC	Female	All	−0.784	<.001	7	view →
KIRC	All	II,III,IV	−0.325	.001	6	view →
UCEC	All	All	−0.917	<.001	4	view →
BRCA	All	All	−0.396	<.001	4	view →
READ	Female	All	−1.261	<.001	2	view →
CHOL	All	All	+0.943	.003	2	view →
PRAD	All	All	−0.412	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PPP2CB–THCA

Open the THCA breakdown →