PPP2CA

Across TCGA patient cohorts, PPP2CA mutation is significantly associated with the RNA expression of many other genes, with 519 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2CA-associated genes across cancer lineages are RNA5SP405, RNA5SP198, and OR4P1P. Each is linked with PPP2CA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2CA-to-partner and partner-to-PPP2CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP405 grouped by PPP2CA-low versus PPP2CA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2CA→partner) and Y-score (partner→PPP2CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP405 →	+0.246	+2.919	<.001	.007	3	2
UCEC	RNA5SP198 →	+0.303	+2.451	.001	.007	3	2
BLCA	OR4P1P →	+0.191	+6.444	<.001	.001	3	2
LUSC	RNU6-984P →	+0.456	+7.327	<.001	<.001	3	2
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	1
CESC	ATF4P2 →	+0.048	+4.409	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 519 associations by consensus.

RNA5SP405 by PPP2CA expression — UCEC

Explore this box plot interactively →