PPP2CA

Across TCGA pan-cancer cohorts, PPP2CA RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PPP2CA data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP2CA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPP2CA expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

HNSC, LIHC, and PAAD are the cancer types where PPP2CA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.501	0.699	<.001	104	view →
LIHC	DFS	Median	All	0.458	0.621	<.001	65	view →
PAAD	OS	Quartile	All	0.270	0.700	<.001	52	view →
KIRC	OS	Median	All	0.733	0.514	<.001	52	view →
UVM	DFS	Quartile	All	0.307	0.844	.003	52	view →
CESC	DFS	Quartile	III,IV	0.559	0.953	.010	48	view →
ESCA	OS	Tertile	All	0.300	0.641	<.001	48	view →
SCLC	DFS	Tertile	All	0.259	0.572	.004	39	view →
KICH	OS	Quartile	II,III,IV	0.488	1.000	.003	37	view →
KIRP	DFS	Quartile	All	0.876	0.976	.005	30	view →
LUAD	OS	Median	All	0.255	0.463	.001	25	view →
READ	DFS	Quartile	All	0.957	0.644	.006	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PPP2CA–HNSC (OS)

Open the HNSC breakdown →