PPP2CA

Across TCGA patient cohorts, PPP2CA mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2CA-associated genes across cancer lineages are JNK2, mTOR_pS2448, and ATM. Each is linked with PPP2CA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2CA-to-partner and partner-to-PPP2CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PPP2CA-low versus PPP2CA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2CA→partner) and Y-score (partner→PPP2CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.193	+2.009	.013	.017	3	2
UCEC	mTOR_pS2448 →	-0.127	-1.584	.029	.036	3	2
UCEC	ATM →	-0.620	-3.156	<.001	.018	3	2
UCEC	4E-BP1 →	+0.432	+2.029	<.001	.017	3	2
UCEC	EGFR_pY1068 →	-0.263	-2.000	.007	.010	3	1
UCEC	eIF4E →	+0.184	+3.459	.026	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

JNK2 by PPP2CA expression — UCEC

Explore this box plot interactively →