PPP2CA

Across TCGA cell cohorts, PPP2CA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,512 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP2CA-associated GO terms across cancer lineages are CAAX-box protein maturation, Negative regulation of protein-containing complex disassembly, and Microtubule polymerization. Each is linked with PPP2CA in more than 14 cancer types. Because this analysis shows association rather than direction, both PPP2CA-to-partner and partner-to-PPP2CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAAX-box protein maturation grouped by PPP2CA-low versus PPP2CA-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2CA→partner) and Y-score (partner→PPP2CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CAAX-box protein maturation →	+0.108	+1.093	<.001	<.001	3	15
SOFT_TISSUE	Negative regulation of protein-containing complex disassembly →	+0.078	+0.880	<.001	.003	3	14
STOMACH	Microtubule polymerization →	+0.100	+0.991	.001	.003	3	14
UPPER_AERODIGESTIVE_TRACT	Response to dehydroepiandrosterone →	+0.203	+1.240	<.001	<.001	3	14
PANCREAS	Positive regulation of mitotic cytokinesis →	+0.153	+0.900	<.001	.001	3	14
SKIN	Phosphatidylinositol biosynthetic process →	+0.070	+0.856	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,512 associations by consensus.

CAAX-box protein maturation by PPP2CA expression — BLOOD_Lymphoma

Explore this box plot interactively →