PPP2CA

Across TCGA cell cohorts, PPP2CA protein abundance is significantly associated with the RNA expression of many other genes, with 2,745 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PPP2CA-associated genes across cancer lineages are CLPP, SMN1, and NPM1. Each is linked with PPP2CA in more than 5 cancer types. Because this analysis shows association rather than direction, both PPP2CA-to-partner and partner-to-PPP2CA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP2CA versus CLPP in PANCREAS, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2CA→partner) and Y-score (partner→PPP2CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CLPP →	+0.695	+1.317	.002	<.001	3	5
PANCREAS	SMN1 →	+0.808	+1.412	<.001	<.001	3	5
PANCREAS	NPM1 →	+0.971	+1.273	.004	.001	3	5
PANCREAS	TIPIN →	+1.061	+1.144	<.001	.006	3	5
SKIN	BYSL →	+0.532	+0.569	.001	.006	2	6
LUNG_SCLC	RPS2 →	+1.174	+1.049	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,745 associations by consensus.

PPP2CA vs CLPP — PANCREAS

Explore this scatter interactively →